:root{color-scheme:light;--bg:#f6f8fc;--surface:#fff;--soft:#edf3fa;--text:#142b42;--muted:#53677e;--border:#c9d7e6;--accent:#036b73;--accent-soft:#d9f2ee;--focus:#7d43b3;--shadow:0 14px 38px #102c4610;--radius:20px}
:root[data-theme="dark"]{color-scheme:dark;--bg:#09131f;--surface:#101f30;--soft:#0c1929;--text:#ebf3fc;--muted:#b5c6d8;--border:#34485f;--accent:#7be1d3;--accent-soft:#153d40;--focus:#dfb1ff;--shadow:0 14px 38px #0003}
:root.a11y-contrast{--bg:#000;--surface:#000;--soft:#080808;--text:#fff;--muted:#eee;--border:#fff;--accent:#8ffff0;--accent-soft:#002b25;--focus:#ff0;--shadow:none}
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label{display:grid;gap:6px;font-size:.88rem;font-weight:700}input[type="search"],select{width:100%;min-height:46px;background:var(--surface);color:var(--text);border:1px solid var(--border);border-radius:10px;padding:.65rem .8rem;min-width:0}.mechanism-grid{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));gap:18px}.mechanism p{font-size:.95rem}.mechanism .source-note{font-size:.8rem}.empty{padding:24px;border:1px dashed var(--border);border-radius:14px;color:var(--muted)}[hidden]{display:none!important}.table-scroll{max-width:100%;overflow-x:auto;border:1px solid var(--border);border-radius:16px;background:var(--surface);overscroll-behavior-inline:contain}table{border-collapse:collapse;min-width:820px;width:100%;font-size:.9rem}caption{text-align:left;padding:16px;color:var(--muted);font-size:.83rem}thead{background:var(--accent-soft);color:var(--accent)}th,td{text-align:left;vertical-align:top;padding:18px;border-top:1px solid var(--border);overflow-wrap:anywhere}th:first-child{width:28%}td:nth-child(2){width:31%}th small{display:block;font-size:.8rem;color:var(--muted);font-weight:450;margin-top:8px}.checklist-grid{display:grid;grid-template-columns:1fr 1fr;gap:20px}.checklist{margin:0;min-width:0}.checklist legend{font-size:1.1rem;font-weight:800;padding-inline:8px}.checklist label{display:flex;align-items:flex-start;gap:12px;padding:12px 0;border-bottom:1px solid var(--border);cursor:pointer}.checklist label:last-child{border-bottom:0}.checklist input{flex-shrink:0;width:21px;height:21px;margin-top:4px;accent-color:var(--accent)}.checklist-footer{display:flex;align-items:center;justify-content:space-between;gap:16px;flex-wrap:wrap;margin-top:20px}#checklistStatus{font-weight:750}.sources{padding-left:24px}.sources li{padding:12px 8px;border-bottom:1px solid var(--border);scroll-margin-top:150px;overflow-wrap:anywhere}.sources li:target{background:var(--accent-soft);border-radius:10px}.sources span{display:block;font-size:.83rem;color:var(--muted);margin-top:5px}.footer{padding-block:32px 48px;border-top:1px solid var(--border);font-size:.86rem;color:var(--muted)}
@media(max-width:900px){.hero{grid-template-columns:1fr;gap:25px;padding-block:40px}.mechanism-grid{grid-template-columns:repeat(2,minmax(0,1fr))}.filters{grid-template-columns:1fr 1fr}.filters button{justify-self:start}.definition-grid{grid-template-columns:1fr}.section{padding-block:36px}}
@media(max-width:600px){html{scroll-padding-top:170px}.wrap{width:calc(100% - 28px)}.header-row{align-items:flex-start}.brand{font-size:.83rem}.brand>span:first-child{font-size:1.5rem}.toolbar{gap:6px;justify-content:flex-end}.toolbar button{font-size:.78rem;padding:.5rem .6rem}.section-nav{gap:16px}.review-strip>.wrap{padding-block:10px}.hero{padding-top:32px}.panel{padding:21px}.mechanism-grid,.checklist-grid,.filters{grid-template-columns:1fr}.section{padding-block:30px}.notice{padding:18px}.checklist-footer .actions{width:100%}.checklist-footer button{flex:1}.source-note{overflow-wrap:anywhere}}
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@media print{:root{--bg:#fff;--surface:#fff;--soft:#fff;--text:#000;--muted:#333;--border:#999;--accent:#003f45;--accent-soft:#fff}html{scroll-padding-top:0}body{background:#fff;color:#000;font-size:10pt}.topbar{position:static}.toolbar,.section-nav,.skip-link,.filters,.checklist-footer .actions,#copyStatus,#storageStatus,noscript{display:none!important}.wrap{width:100%}.hero{grid-template-columns:1fr 1fr;padding:20px 0;gap:18px}.section{padding:18px 0}.panel,.notice{box-shadow:none;background:#fff;border-color:#aaa;padding:14px}.soft,.review-strip{background:#fff}.definition-grid,.mechanism-grid{grid-template-columns:repeat(3,1fr)}.table-scroll{overflow:visible;border:none}table{min-width:0;font-size:8pt}th,td{padding:8px}thead{display:table-header-group}tr,.panel{break-inside:avoid}h1{font-size:25pt}h2{font-size:19pt}.meta,.source-note,.sources span{color:#333}.mechanism[hidden],#doseBody tr[hidden]{display:table-row!important}.mechanism[hidden]{display:block!important}.sources li{padding:7px 0}.sources a[href]:after{content:" (" attr(href) ")";font-size:7pt;color:#333}.pill{background:#eee;color:#000}}